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近年来,天然产物姜黄素因其显著的抗肿瘤等多种生物活性引起广泛关注.然而姜黄素水溶性差、化学结构不稳定、生物利用度低,限制了其在临床上的进一步应用.用小分子或大分子载体对姜黄素的酚羟基进行修饰制备得到的姜黄素前药能较好地解决姜黄素上述的缺点,也是改善姜黄素成药性的有效策略.综述了近年来国内外姜黄素前药的研究进展.
In recent years, curcumin, a natural product, has attracted a great deal of attention due to its remarkable anti-tumor activity, etc. However, curcumin has poor water solubility, unstable chemical structure and low bioavailability, which limits its further clinical application. Or macromolecular carrier curcumin modified phenolic hydroxyl prepared curcumin prodrug can better solve the above shortcomings of curcumin is also an effective strategy to improve the drug curcumin an effective strategy is summarized in recent years at home and abroad curcumin prodrug Research progress.