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目的:探究凝血、纤溶和纤维化与慢性乙型肝炎病毒感染状态的关系。方法:选取我院收治的慢性乙型病毒肝炎患者120例,经检测后将患者分为免疫清除组40例、免疫耐受组40例、非活动性组40例和对照组40例,分别检测每组患者的凝血功能、纤溶和纤维化的水平以及统计与感染状态的相关程度。结果:与对照组相比,其余各组凝血功能降低(P<0.05),纤溶和纤维化水平明显升高(P<0.05);与非活动组和免疫耐受组相比,免疫清除组患者的各项指标变化明显(P<0.05);非活动组与免疫耐受组相比各项指标大多无统计学差异(P>0.05);经统计凝血、纤溶和纤维化与HBV具有相关性,凝血功能与HBV呈负相关,纤溶与HBV呈正相关,纤维化与HBV呈正相关。结论:患者慢性乙型肝炎病毒感染状态不同,其凝血、纤溶和纤维化水平含量有明显差异,可作为疾病发展的监测依据,临床上值得推广。
Objective: To investigate the relationship between coagulation, fibrinolysis and fibrosis and chronic hepatitis B virus infection. Methods: A total of 120 patients with chronic hepatitis B admitted to our hospital were enrolled and divided into 40 cases of immune clearance group, 40 cases of immunocompromised group, 40 cases of inactive group and 40 cases of control group. Coagulation, fibrinolysis and fibrosis levels in each group of patients, as well as statistical correlations with the status of infection. Results: Compared with the control group, the coagulation function was decreased (P <0.05) and fibrinolysis and fibrosis were significantly increased in the other groups (P <0.05). Compared with the inactive group and the immunocompromised group, (P <0.05). There was no significant difference between the inactive group and the immune tolerance group (P> 0.05). According to the statistics, coagulation, fibrinolysis and fibrosis were correlated with HBV Sex, coagulation function and HBV was negatively correlated, fibrinolysis and HBV was positively correlated, fibrosis and HBV was positively correlated. Conclusion: The patients with chronic hepatitis B virus infection in different states, the coagulation, fibrinolysis and fibrosis levels were significantly different, can be used as a monitoring basis for the development of the disease, clinically worthy of promotion.