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目的:评价门冬氨酸鸟氨酸与食醋灌肠联用治疗肝性脑病患者的临床疗效。方法:选取2012年3月—2015年3月间诊治的肝性脑病患者84例作为研究对象,采用抽签法将其分为观察组(n=42)与对照组(n=42);对照组患者在护肝等常规治疗方案下均给予食醋灌肠治疗,观察组患者在对照组的基础上均给予门冬氨酸鸟氨酸静脉滴注治疗;比较两组患者治疗后肝功能、神经系统等各项指标的改善情况。结果:观察组患者治疗后的总有效率为92.9%显著高于对照组为71.4%(χ~2=6.574,P<0.05);ALT、AST、TBil值以及血氨指标均低于对照组(P<0.05)。结论:门冬氨酸鸟氨酸静脉滴注与食醋灌肠联用治疗肝性脑病患者起到较好的疗效,降低了血氨含量,改善了肝功能及精神状态。
Objective: To evaluate the clinical efficacy of ornithine aspartate combined with vinegar enema in the treatment of patients with hepatic encephalopathy. Methods: Eighty-four patients with hepatic encephalopathy who were diagnosed and treated between March 2012 and March 2015 were selected as the study subjects. The patients were divided into observation group (n = 42) and control group (n = 42) Patients under the routine treatment programs such as liver protection given vinegar enema treatment, patients in the observation group were given aspartate ornithine intravenous infusion on the basis of the control group; compared two groups of patients after treatment of liver function, nervous system And other indicators of the improvement. Results: The total effective rate of observation group was 92.9%, which was significantly higher than 71.4% (χ ~ 2 = 6.574, P <0.05). The levels of ALT, AST, TBil and blood ammonia were lower than those of control group P <0.05). Conclusion: Aspartate ornithine intravenous infusion combined with vinegar enema treatment of patients with hepatic encephalopathy played a good effect, reducing blood ammonia, improve liver function and mental status.