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目的探讨小剂量剂型锝—亚甲基二膦酸盐注射液(99Tc—MDP,云克)不同临床应用方式治疗类风湿关节炎(RA)的疗效。方法将临床确诊的36例活动期类风湿关节炎患者,均衡随机分成两组,应用小剂量剂型(5.5mg)云克分别采用单纯静脉推注法和混合注射法进行治疗,并以病变关节功能受累情况、实验室指标及临床表现分为轻、中、重三类,分别评价其治疗效果。结果两组显效7例(19.4%),有效20例(55.6%),无效9例(25.0%),总有效率75.0%。混合注射法早期疗效反应及效果明显早于和优于单纯静脉推注法。病情轻、中、重度患者总有效率分别为80.0%、76.2%和60.0%。结论提示小剂量剂型云克治疗RA简便安全,疗效满意,副作用少,值得临床推广应用。对不同病情患者,选择不同给药方式有不同疗效,且疗效依病情轻重而差别较大。
Objective To investigate the curative effect of different dosages of technetium-methylene diphosphonate (99Tc-MDP, Yunke) on rheumatoid arthritis (RA). Methods A total of 36 patients with active rheumatoid arthritis were divided into two groups randomly. The patients were treated with low dose (5.5mg) of Yunke by simple intravenous injection and mixed injection respectively. The patients with rheumatoid arthritis Involved in the situation, laboratory indicators and clinical manifestations were divided into light, medium and heavy three categories, respectively, to evaluate the therapeutic effect. Results The two groups were markedly effective in 7 cases (19.4%), effective in 20 cases (55.6%), ineffective in 9 cases (25.0%), the total effective rate was 75.0%. The early response and the effect of mixed injection were earlier and better than simple intravenous injection method. The mild, moderate and severe patients with total effective rates were 80.0%, 76.2% and 60.0%. The conclusion suggests that the low dose of Yunke is a simple and safe treatment of RA with satisfactory curative effect and less side effects, which is worthy of clinical application. Different conditions of patients, choose different modes of administration have different curative effect, and the efficacy varies depending on the severity of illness.