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[目的]探讨p16基因缺失在鼻咽癌中的临床意义。[方法]采用多重PCR分析法,对157例鼻咽癌标本p16基因突变情况进行检测。[结果]鼻咽癌组织中p16基因第2外显子的缺失率为35.0%(55/157)。p16基因第2外显子的缺失与鼻咽癌的临床分期、性别、年龄无显著性相关,但生存期<3年者的p16基因第2外显子的缺失率高于生存期>3年者(69.57%vs.29.10%,χ2=14.12,P=0.000)。[结论]p16基因第2外显子可能与鼻咽癌的发生、发展和预后有关。
[Objective] To investigate the clinical significance of p16 gene deletion in nasopharyngeal carcinoma. [Methods] Multiplex PCR was used to detect the mutation of p16 gene in 157 cases of nasopharyngeal carcinoma. [Results] The deletion rate of exon 2 of p16 gene in nasopharyngeal carcinoma was 35.0% (55/157). The deletion of exon 2 of p16 gene was not associated with the clinical stage, gender and age of NPC, but the deletion rate of exon 2 of p16 gene in survival <3 years was higher than that of survival> 3 years (69.57% vs.29.10%, χ2 = 14.12, P = 0.000). [Conclusion] The exon 2 of p16 gene may be related to the occurrence, development and prognosis of nasopharyngeal carcinoma.