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目的 检测金属硫蛋白在正常肝脏和肝细胞癌组织中的表达并探讨其临床意义。方法 采用多克隆抗体免疫组化染色技术对20例肝细胞癌及正常肝组织(包括癌周边肝组织)中金属硫蛋白(Metallothionein MT)的表达进行了分析。结果 正常肝组织中有很强的MT染色(3.2±0.6),而肝癌组织中MT染色很弱甚至无MT染色(1.4±0.5),二者相比P<0.001。结论 MT表达在肝癌组织和正常肝组织明显不同,其结果具有重要的理论研究和临床应用价值。
Objective To detect the expression of metallothionein in normal liver and hepatocellular carcinoma and explore its clinical significance. Methods The expression of metallothionein (MT) in 20 cases of hepatocellular carcinoma and normal liver tissues (including hepatic tissues) was analyzed by polyclonal antibody immunohistochemical staining. Results There was a strong MT staining in normal liver tissues (3.2±0.6), while MT staining in liver cancer tissues was very weak or even without MT staining (1.4±0.5). P<0.001 compared with the two. Conclusion The expression of MT is obviously different between hepatoma tissue and normal liver tissue. The results have important theoretical research and clinical application value.