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肠道病毒是在探索更好地了解及控制脊髓灰质炎的过程中发现的。1948年,从麻痹性脊髓灰质炎患者的粪便标本中分离了第一株现称为A组柯萨基病毒的毒株。一年之后,又发现了认为是无菌性脑膜炎以及流行性肌痛和胸痛的病原体的B组柯萨基病毒。以后两年中,发现柯萨基A组病毒能引起疱疹性咽峡炎和脑膜炎,B组柯萨基病毒能引起心肌炎。1943年中国病毒学家黄祯祥和1950年John Enders在病毒研究领域中采用了新的简便的组织培养方法,之后不久,识别了大量对
Enteroviruses are found in the quest to better understand and control poliomyelitis. In 1948, the first isolate, now known as the Coxsackievirus A virus, was isolated from stool specimens from patients with paralytic poliomyelitis. A year later, the group C coxsackievirus that was identified as a mycotic aseptic meningitis and a pathogen of myalgia and chest pain was also found. In the next two years, Coxsackie A virus was found to cause herpes angina and meningitis, and C group Coxsackie virus caused myocarditis. Chinese virologist Huang Zhenxiang in 1943 and John Enders in 1950 adopted a new and simple method of tissue culture in the field of virus research. Shortly thereafter,