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1目的 探讨转化生长因子 β1 (TGFβ1 )在非小细胞肺癌中表达的意义。 2方法 应用免疫组化法检测了 12 1例非小细胞肺癌标本中 TGFβ1 的表达。 3结果 TGFβ1 在肺癌中的阳性表达率为 77.7% ,其阳性表达分为间质型和胞浆型 ,表达类型与肺癌淋巴结转移及预后有关。淋巴结转移阳性组中 TGFβ1 的间质阳性表达率显著低于阴性组 ,而其胞浆阳性表达率显著高于阴性组 (χ2 =10 .0 1,2 1.98,P<0 .0 1) ;0 .5年内死亡组的 TGFβ1 间质阳性表达率显著低于生存 >5 .0年组 ,而间质胞浆均阳性及胞浆阳性表达率则显著高于生存 >5 .0年组 (χ2 =8.2 1,7.6 3,P<0 .0 5 )。 4结论 TGFβ1 表达与肺癌恶性生物学行为关系明显 ,是估测病人预后的有效参数之一。
1 Objective To investigate the significance of transforming growth factor β1 (TGFβ1) expression in non-small cell lung cancer. 2 Methods The expression of TGFβ1 in 12 1 non-small cell lung cancer specimens was detected by immunohistochemistry. 3 Results The positive rate of TGFβ1 in lung cancer was 77.7%. The positive expression of TGFβ1 was divided into interstitial and cytoplasmic types. The expression of TGFβ1 was related to lymph node metastasis and prognosis of lung cancer. The positive rate of interstitial expression of TGFβ1 in lymph node positive group was significantly lower than that in negative group, but the positive rate of cytoplasm expression in lymph node positive group was significantly higher than that in negative group (χ2 = 10.012 1.98, P <0.01). . The positive rate of TGFβ1 expression in the death group was significantly lower than that of the surviving group> 0.05 in five years, while the positive rate of cytoplasm in the interstitial cytoplasm was significantly higher than that in the survival> 5.0 year group (χ2 = 8.2 1,7.6 3, P <0. 05). 4 Conclusion TGFβ1 expression and malignant biological behavior of lung cancer significantly, is to estimate the prognosis of patients with one of the effective parameters.