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我们采用ＰＣＲ－ＲＦＬＰ（限制性片段长度多态性分析）检测ＨＢＶ多聚酶基因ＹＭＤＤ变异，并将其与核苷酸序列测定结果进行比较，现报道如下。 一、材料与方法 １．病例来源：４３份标本采自从１９９７—２０００年在本院接受拉米夫定长期治疗的慢性乙型病毒性肝炎患者，其
We used PCR-RFLP (restriction fragment length polymorphism analysis) to detect HBV polymerase gene YMDD mutation, and compared with the nucleotide sequence determination results are reported below. First, materials and methods 1. Source: 43 samples collected from patients with chronic hepatitis B who underwent long-term treatment with lamivudine in our hospital from 1997 to 2000,