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本文报告和分析了20例小儿IgA肾病的免疫荧光表现及其与临床表现和病理改变之间的关系。8例IgA单独沉积于系膜区(组1);12例同时有毛细血管壁沉积(组2)。临床上以急性肾炎和持续血尿起病者均在组2。两组虽各有1例肾病综合征,但组1病例对皮质激素治疗呈完全效应,组2病例则为部分效应。组2肾小球病变≥2度,肾小管间质病变≥++者显著多于组1(P <0.05)。肾小球有无IgM沉积和小球有无硬化改变无关。虽然IgA荧光强度≥++在组2显著多于组1(P<0.05),但≥+++两组无显著差异。
This article reports and analyzes the immunofluorescence of 20 children with IgA nephropathy and its relationship with clinical manifestations and pathological changes. Eight cases of IgA deposited in the mesangial area alone (Group 1); 12 cases also had capillary wall deposits (Group 2). Clinically, patients with acute nephritis and persistent hematuria are in group 2. Although there was one nephrotic syndrome in each of the two groups, the group 1 had a complete effect on corticosteroid treatment and the group 2 had a partial effect. Group 2 glomerular lesions ≥ 2 degrees, tubulointerstitial lesions ≥ ++ were significantly more than group 1 (P <0.05). Glomerular IgM deposition has nothing to do with the change of the sclerosis. Although IgA fluorescence intensity ≥ ++ was significantly more in group 2 than in group 1 (P <0.05), there was no significant difference between groups ≥ +++.