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D~u血型相当少见,白种人D~u表现型频率为0.6%,产生抗D的D~u型(即D型伴有抗D)则更少见。本文报告1例Rh阳性D~u变异的母亲由于抗D引起致命性新生儿溶血病。患者为白种人,女性,26岁。3孕1产,未输过血。第一个孩子(ccDEe)因肠梗阻夭折。第二个孩子死于脐带引起的宫内窘迫。这2次妊娠中均未观察到Rh血型不合引起的并发症。第三次妊娠中,查血型为O、CcD~uee型,抗体筛选试验血清不起反应。此次妊娠8个月时体重增加36磅,腹部极度膨隆,产前检查发现在后2周内体重增加12磅,血清中含抗D抗体,立即剖腹取胎。婴儿有明显水肿,腹部膨隆,发绀。
D ~ u blood type is quite rare, Caucasian D ~ u phenotype frequency of 0.6%, to produce anti-D D ~ u type (that is, D-type with anti-D) is even more rare. This article reports a case of Rh-positive D ~ u mutation mothers due to anti-D-induced fatal neonatal hemolytic disease. The patient is Caucasian, female, 26 years old. 3 pregnant 1 production, did not lose blood. The first child (ccDEe) died of intestinal obstruction. The second child died of intrauterine distress caused by the umbilical cord. No complication caused by Rh blood group incompatibility was observed in these two pregnancies. The third pregnancy, check blood type O, CcD ~ uee type, antibody screening test serum can not react. At 8 months of pregnancy, the weight increased by 36 pounds and the abdomen was extremely bulging. An antepartnum examination revealed an increase of 12 pounds in the first 2 weeks. The serum contained anti-D antibody and immediate cesarean section. Infants have obvious edema, bulging belly, cyanosis.