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骨骼是晚期恶性肿瘤最常见的转移部位。随着抗癌治疗方法的不断改进,晚期癌症患者的生存时间不断延长,患者出现骨转移及其他骨骼并发症的风险也随之明显增加。目前对于恶性肿瘤骨转移的基本治疗方法包括:镇痛药物治疗、二膦酸盐类药物治疗、放射治疗、化学治疗、内分泌及分子靶向治疗。治疗目标为缓解疼痛、恢复功能和提高生活质量[1,2]。近年来发现临床长期应用二膦酸盐类药物,尤其长期大剂量静脉注射二膦酸盐(bisphosphonate,
Bones are the most common sites of metastases in advanced malignancies. With the continuous improvement of anticancer therapies, the survival of patients with advanced cancer continues to increase, the risk of patients with bone metastases and other bone complications also increased significantly. Currently, the basic treatment of bone metastases of malignant tumors include: analgesics, bisphosphonates, radiation therapy, chemotherapy, endocrine and molecular targeted therapy. The goal of treatment is to relieve pain, restore function and improve quality of life [1,2]. In recent years, clinical long-term use of bisphosphonates, especially long-term high-dose intravenous bisphosphonate (bisphosphonate,