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目的对于进展期结直肠癌肝转移化疗敏感的患者,分期肝转移癌切除以延长生存期应是首选治疗模式,而完整切除术对这部分患者的生存影响仍有争议。患者与方法自2002年6月至2010年2月,单中心前瞻性纳入连续手术患者890例,单纯化疗患者879例。评估分期肝切除术后生存情况采用意向治疗分析。拟进行分期肝切除的进展期肝脏双叶受累患者,首先应对化疗敏感,首次局限性手术可以清除病灶较少的一侧肝脏,而二次手术时对对侧肝脏病灶进行扩大切
Objective To investigate the effect of complete resection on the survival of patients with advanced colorectal cancer with liver metastases and chemosensitivity of staging liver metastases to prolong survival should be the first choice of treatment. Patients and Methods From June 2002 to February 2010, a single center prospectively enrolled 890 consecutive patients and 879 patients with chemotherapy alone. Survival after staged liver resection was assessed using intention-to-treat analysis. The patients with progressive liver bipolar involvement who are scheduled for hepatectomy should first be sensitive to chemotherapy. The first limited operation can clear the lesion on the side of liver, while the second operation enlarges the contralateral liver lesion