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目的：探讨结核菌Ｌ型与肺癌的可能关系。方法：应用改良抗酸染色法及免疫酶染色法，对９６例经纤维支气管镜活检标本及２０例手术切除肺标本进行结核菌及其Ｌ型的检测。结果：９３例肺癌组织抗酸染色及免疫酶染色阳性率分别为３８．７１％和５１．６１％，均高于非肺癌非肺结核（对照）组（Ｐ＜０．０１和Ｐ＜０．０５）；抗酸染色所检出的结核菌除１例为典型杆菌外，其余都为Ｌ型；免疫酶染色阳性中，有２９．１７％阳性颗粒见于癌细胞中，有６．２５％见于细胞核内。结论：结核菌Ｌ型失去细胞壁后，与病毒特性相似，可与体细胞融合，将其ＤＮＡ整合到宿主细胞染色体上，在肺癌发生中可能起一定作用。
Objective: To investigate the possible relationship between tuberculosis L-form and lung cancer. METHODS: Mycobacterium tuberculosis and its L-form were detected in 96 biopsy specimens and 20 surgically resected lung specimens using modified acid-fast staining and immunoenzymatic staining. Results: The positive rates of acid-fast staining and immuno-enzyme staining of lung cancer tissues were 38.71% and 51.61%, respectively, which were higher than those of non-lung cancer non-tuberculosis (control) groups (P<0.01 and P<0.05). The TB strains detected by acid-fast staining were L-type except for one case of typical bacillus; 29.71% positive particles were found in cancer cells and 6.25% were found in nucleus in positive immuno-enzyme staining. Inside. Conclusion: L-form of L. tuberculosis after losing cell wall is similar to that of virus. It can be fused with somatic cells and integrate its DNA into the chromosome of host cells. It may play a role in the development of lung cancer.