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目的：探讨加味生脉散增强机体热耐受力的作用机理。方法：以ＳＤ大鼠制备热损伤模型，观察加味生脉散对热损伤大鼠血浆糖皮质激素（ＧＣ）、促肾上腺皮质激素（ＡＣＴＨ）以及脑、肝胞液糖皮质激素受体（ＧＣＲ）的影响。结果：发现加味生脉散组大鼠脑、肝胞液ＧＣＲ的结合活性（Ｒｓ）（５３．１７±１４．０６，３３２．２３±５３．８３）明显高于单纯热损伤组（２８．２７±１０．２７，２１６．９０±６８．９７），同时并不降低血浆ＧＣ和ＡＣＴＨ的浓度。结论：加味生脉散通过保护ＧＣＲ提高机体ＧＣ系统在热应激过程中的生物学效应，可能是其增强机体热耐受力的重要作用机理之一。
Objective: To explore the mechanism of enhancing the thermal tolerance of the body by adding Shengmaisan. METHODS: A thermal injury model was established in SD rats. The effects of Shengmaisan on plasma glucocorticoid (GC), adrenocorticotropic hormone (ACTH) and cerebral and hepatic cytoplasmic glucocorticoid receptor (GCR) were observed. Impact. RESULTS: The GCR binding activity (Rs) in brain and hepatic fluid of rats in Modified Shengmaisan group was significantly higher than that in simple thermal injury group (53.17±14.06,332.23±53.83) (28.27). ± 10.27, 216.90 ± 68.97), while not decreasing plasma GC and ACTH concentrations. Conclusion: Modified Shengmaisan can improve the biological effects of GC system during heat stress by protecting GCR, which may be one of the important mechanisms of its enhancement of body heat tolerance.