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目的 :观察黄芩煎剂对四氯化碳 ( CCL 4)化学性肝损伤的保护作用。方法 :建立CCL 4致大鼠急性肝损伤模型 ,设黄芩煎剂大、中、小剂量组和正常对照组及模型对照组 ,通过测定各组动物血清谷丙转氨酶 ( AL T)、山梨醇脱氢酶 ( SDH)活性及肝糖原、肝脏系数和观察肝脏组织病理学变化 ,以评价肝脏损伤程度和药物的保护作用。结果 :黄芩煎剂各剂量组大鼠血清 AL T、SDH活性及肝脏系数均降低 ,肝糖原合成增加 ,肝脏组织病理损伤得到明显改善 ,且呈明显的量效关系。结论 :黄芩煎剂对 CCL4致动物急性肝损伤具有良好的保护作用
Objective: To observe the protective effect of Huangqi decoction on carbon tetrachloride (CCL 4) chemical liver injury. METHODS: A rat model of acute liver injury induced by CCL 4 was established. The large, medium, and small doses of Huangqi decoction were used as well as the normal control group and the model control group. Serum alanine aminotransferase (AL T) and sorbitol were measured in each group. Hydrogenase (SDH) activity, hepatic glycogen, liver coefficient, and histopathological changes in liver tissue were evaluated to evaluate the degree of hepatic injury and the protective effect of the drug. Results : The serum AL T, SDH activity and liver coefficient of the rats in each dose group of Huangqi decoction were decreased, liver glycogen synthesis was increased, liver pathological damage was significantly improved, and there was a significant dose-effect relationship. Conclusion : Huangqi decoction has a good protective effect on acute liver injury caused by CCL4 in animals