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血管紧张素转换酶(ACE)催化血管紧张素Ⅰ成为血管紧张素Ⅱ。此酶主要存在于血管内皮细胞的管腔面上,由于在肾和肺内含有大量ACE,该两个器官被认为是血浆ACE的主要来源。已知在结节病和慢性肺疾患中血浆ACE活性异常,已有报告称在长期血透的慢性肾衰病人中约60%有ACE活性增高。本文报告43例慢性肾衰病人中血ACE活性测定的结果,并探讨其机制。全组中26例为终末期肾病病
Angiotensin-converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II. This enzyme is found predominantly on the luminal surface of vascular endothelial cells, which are considered to be the main source of plasma ACE due to the high amounts of ACE contained in the kidney and lung. Plasma ACE activity is known to be abnormal in sarcoidosis and chronic lung disease and it has been reported that about 60% of patients with chronic renal failure who have long-term hemodialysis have increased ACE activity. This article reports 43 cases of chronic renal failure in patients with ACE activity test results and explore its mechanism. The whole group of 26 cases of end-stage renal disease