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目的探讨玻璃纤维粉尘与甲醛联合对呼吸系统3项脂质过氧化指标及外周血淋巴细胞微核率的影响。方法选择玻璃纤维厂、家具厂及对照厂共150人,分为3组,即玻璃纤维粉尘+甲醛组、甲醛组、对照组,每组50名。检测超氧化物歧化酶、丙二醛及谷胱甘肽过氧化物酶等3项脂质过氧化指标及外周血淋巴细胞微核率。结果鼻炎、咽炎、肺纹理增多增粗、紊乱以及小气道通气功能轻度障碍发生率各组间比较,粉尘+甲醛组的发生率明显高于其他两组(P<0.05);3项脂质过氧化指标各组间比较,差异无显著性;而外周血淋巴细胞微核率各组间比较差异有显著性(P<0.05)。结论玻璃纤维粉尘与甲醛有一定的协同作用,对呼吸系统和细胞的毒性有一定的影响,需认真做好防护工作。
Objective To investigate the effects of combination of glass fiber dust and formaldehyde on the lipid peroxidation index and micronucleus rate of peripheral blood lymphocytes in the respiratory system. Methods A total of 150 glass fiber factories, furniture factories and control plants were selected and divided into three groups, namely, glass fiber dust + formaldehyde group, formaldehyde group and control group with 50 in each group. Three lipid peroxidation indexes, such as superoxide dismutase, malondialdehyde and glutathione peroxidase, and micronucleus rate of peripheral blood lymphocytes were detected. Results The incidences of rhinitis, pharyngitis, increased lungs thickening, disorganization and mild airway dysfunction were significantly higher in the dust + formaldehyde group than in the other two groups (P <0.05). The three lipids There was no significant difference in the indexes of peroxidation among the groups. There was significant difference in the micronucleus rate of peripheral blood lymphocytes between the groups (P <0.05). Conclusion The glass fiber dust and formaldehyde have a certain synergistic effect on the respiratory system and cell toxicity have a certain impact, we must seriously do the work of protection.