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应用X线照射的血内伯氏鼠疟原虫,或血内伯氏鼠疟原虫的水不溶性部分,或X线照射的子孢子作为疫苗,接种啮齿类防御活的伯氏鼠疟原虫攻击感染已获得了成功,并已证明这些疫苗具有期的特异性。本文概述了一种没有危险的现场试验方法及类似的疫苗预防人体恶性疟的效力。强调指出:(1)在没有模型的情况下虽能测试疫苗的效力,但仅能测试疫苗对人体恶性疟原虫的预防作用;(2)衡量防护作用应以防止发病和防止死亡为依据;(3)为了适应需要,必须加强大量繁殖疟原虫裂殖子和/或子孢子的研究,并寻找增高人体防御恶性疟原虫的免疫反应水平的方法。
X-ray irradiation intradermal Plasmodium falciparum, or the blood of the intradermal Plasmodium falciparum water-insoluble fraction, or X-ray irradiation sporozoites as a vaccine, inoculated rodents defensive live P. murine parasite infection has been Success has been achieved and these vaccines have proved to be of period specificity. This article outlines a non-hazardous field test method and similar vaccine to prevent the effectiveness of human falciparum malaria. Emphasized that: (1) Although the vaccine can be tested for efficacy in the absence of a model, it can only be tested for the prophylactic effect of the vaccine on P. falciparum; (2) the measure of protection should be based on prevention of morbidity and mortality; 3) In order to meet the needs, it is necessary to intensify the research on breeding large numbers of merozoites and / or sporozoites in Plasmodium and to find ways to increase the level of human immune defense against Plasmodium falciparum.