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由于60年代用抗疟药治疗的类风湿关节炎和全身性红斑狼疮患者中出现几例角膜沉积和黄斑损伤,于是建议对这类病人均由眼科专家定期检查。但是从1982年所见的报道看来,在服磷酸氯喹250mg/d的病人中仅有13人出现黄斑病变和视敏度减退,用硫酸羟氯喹400mg/d治疗的99例病人中仅有4例在以后1～8年中出现视网膜症状,但无1例丧失视力,且停药后均能恢复。最近在俄亥俄州的调查结果表明,服磷酸氯喹4mg/kg/d或羟氯喹6.5mg/kg/d的400例病人在7年中均无出现黄斑病变。这些情况均说
Because of several cases of corneal deposition and macular degeneration in patients with rheumatoid arthritis and systemic lupus erythematosus who were treated with antimalarial drugs in the 1960s, it is recommended that such patients be regularly examined by eye specialists. However, as seen in the 1982 report, only 13 of the patients treated with chloroquine phosphate 250 mg / d developed macular degeneration and decreased visual acuity. Of the 99 patients treated with hydroxychloroquine 400 mg / d, only 4 Cases of retinal symptoms in the next 1 to 8 years, but no case of loss of vision, and can recover after stopping. A recent survey in Ohio showed that 400 patients treated with chloroquine phosphate 4 mg / kg / d or hydroxychloroquine 6.5 mg / kg / d had no macular degeneration for seven years. All these say