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吉林省延边地区１９９６年６月发生无菌性脑膜脑炎流行，在全地区２１６万人口中，发病人数约５～６千人，死亡２人，为历史上所罕见。从病人脑脊液和粪便标本中分离到多株病毒，分离率较高（分别达到５２．４％和６６．７％）。用ＷＨＯ提供的ＲＩＶＭ肠道病毒组合血清进行中和定型，不能确定型别。ＲＴ－ＰＣＲ结果表明为肠道病毒。病人早期血清特异性ＩｇＭ抗体阳性率７２．０％，证明所分离的病毒为此次无菌性脑膜脑炎暴发流行的病因。此病毒为肠道病毒，有可能是肠道病毒的一个新型别或变异株。有关的研究正在深入进行
The epidemic of aseptic meningoencephalitis occurred in June 1996 in Yanbian area of Jilin Province. Among the 2.16 million population in the whole region, the number of cases is about 5 to 6,000 with 2 deaths, which is rare in history. Multiple viruses were isolated from the cerebrospinal fluid and stool specimens of patients, with high rates of isolation (52.4% and 66.7%, respectively). Neutralizing the typing with the combination of RIVM enterovirus provided by WHO, can not determine the type. RT-PCR results indicate enterovirus. The positive rate of early serum-specific IgM antibody in patients was 72.0%, which proved that the isolated virus was the etiology of the epidemic of aseptic meningoencephalitis. This virus is enterovirus, may be a new type or variant of enterovirus. The relevant research is in progress