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对150例病毒性肝炎病人采用免疲荧光抗体法进行了外周血 T 淋巴细胞亚群的检测,以30名健康人为对照,并探讨了该亚群与 ALT、HBV—M的关系。与对照组相比,AH、CPH、CAH、LC 组,除 LC 组 CD_8~+,AH 组 CD_4~+/CD_8~+外,CD_3~+、CD_4~+、CD_8~+、CD_4~+/CD_8~+均明显减少(P<0.01),但各临床分型闻无显著差异(P>0.05);ALT 50u 以下及以上组,除50u 以下组CD_8~+,51u 以上组 CD_4~+/CD_8~+外,CD_3~+、CD_4~+、CD_8~+、CD_4~+/CD_8~+均明显减少(P<0.01);CAH 的HBeAg(+)和(或)抗 HBcIgM(+)组、抗 HBs(+)和(或)抗 HBe(+)组只有 CD_3~+、CD_4~+明显减少(P<0.01),HBeAg(+)和(或)抗 HBcIgM(+)组 CD_4~+/CD_8~+减少(P<0.05)。
Totally 150 peripheral blood T lymphocyte subsets were detected by immunofluorescent antibody in 150 patients with viral hepatitis, and 30 healthy individuals were used as controls. The relationship between ALT and HBV-M was also discussed. Compared with the control group, the levels of CD_3 ~ +, CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / CD_8 in AH, CPH, CAH and LC groups were significantly higher than those in LC group (P <0.01), but there was no significant difference among clinical subtypes (P> 0.05). In the groups below 50u ALT, CD_4 ~ + / CD8 ~ +, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 ~ + in CAH were significantly decreased (P <0.01) CD_4 ~ +, CD_4 ~ + and CD_4 ~ + / CD_4 ~ + of HBeAg + and / or anti HBegM + group were significantly decreased (P <0.01) Decrease (P <0.05).