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从水黄连(Thalictrum simplex)干燥地上部分分离出0.1％生物碱,其中(—)-thalimonine占生物碱总量的8.7％。文献报道高浓度的(—)-thalimonine对睥细胞有毒性作用。本实验对安全使用浓度在0.1～100μM的生物碱(—)-thalimonine的抗病毒和免疫作用进行了研究。结果:在浓度为10μM/mli时(—)-thalimonine对小牛肾细胞(MDBK)和
A 0.1% alkaloid was isolated from the dried aerial part of Thalictrum simplex, and (-)-thalimonine accounted for 8.7% of the total alkaloids. It has been reported in the literature that high concentration of (-)-thalimonine has a toxic effect on sputum cells. In this study, the antiviral and immune effects of safe use of alkaloid (-)-thalimonine at a concentration of 0.1 to 100 μM were studied. Results: (-)-thalimonine on calf kidney cells (MDBK) at a concentration of 10 μM/mli