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目的 :探讨内皮素 (ET)及氧自由基 (OFR)在急性胰腺炎 (AP)发病中的作用及相互关系。方法 :采用放射免疫分析法、硫代巴比妥酸法及黄嘌呤氧化酶法测定 17例重症急性胰腺炎 (SAP)、3 5例轻症急性胰腺炎 (MAP)及 3 0例正常对照 (NC)组血浆 ET、血清丙二醛 (MDA)及超氧化物歧化酶 (SOD)的含量。结果 :SAP患者 ET显著增高 ,MAP患者 ET明显降低 ,两组比较具有显著差异 (P<0 .0 0 1)。 AP患者 MDA显著增高 ,而 SOD明显降低。 SAP与 MAP两组患者 MDA比较具有显著差异 (P<0 .0 0 1) ,而两组患者 SOD比较无显著差异 (P>0 .0 5 )。结论 :OFR损伤是 AP发病的重要因素之一。本文提示 ,ET水平增高协同 OFR参与 SAP发病机制 ,ET水平降低对 MAP胰腺组织可能具有一定的保护作用。
Objective: To investigate the role and relationship of endothelin (ET) and oxygen free radical (OFR) in the pathogenesis of acute pancreatitis (AP). Methods: Seventeen patients with severe acute pancreatitis (SAP), 35 mild to severe acute pancreatitis (MAP) and 30 normal controls were measured by radioimmunoassay, thiobarbituric acid and xanthine oxidase NC), serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD). Results: ET was significantly increased in patients with SAP, ET was significantly lower in patients with MAP, there was significant difference between the two groups (P <0.001). AP patients with MDA increased significantly, while SOD decreased significantly. There was significant difference in MDA between SAP and MAP (P <0.01), but there was no significant difference between the two groups (P> 0.05). Conclusion: OFR injury is one of the important factors in the pathogenesis of AP. This paper suggests that elevated ET levels in conjunction with OFR participate in the pathogenesis of SAP, reduced ET levels may have a protective effect on MAP pancreatic tissue.