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目的探讨耐大环内酯类抗菌药的肺炎支原体感染患儿的用药方案。方法分析2010年11月至2012年5月广东省妇幼保健院收治的咽拭子肺炎支原体培养阳性患儿的用药方案,并回访用药疗程。结果 MP培养阳性患儿116例均使用了大环内酯类抗菌药抗感染治疗,其中耐药52例,除去3例联合了β内酰胺类抗菌药,耐药组为49例;敏感组为64例,没有联合β内酰胺类抗菌药病例。两组的年龄、性别,大环内酯类抗菌药、解热药、抗组胺药、化痰药的使用率差异无统计学意义,P>0.05。耐药组大环内酯类抗菌药的疗程短于敏感组,而解热药、抗组胺药和化痰药的疗程均长于敏感组,差异有统计学意义,P<0.05。结论耐大环内酯类抗菌药的肺炎支原体感染患儿采用大环内酯类抗菌药、解热药、抗组胺药和化痰药治疗,与大环内酯类抗菌药敏感的肺炎支原体感染患儿相比,耐药患儿使用大环内酯类抗菌药的疗程短,使用解热药、抗组胺药和化痰药的疗程长。
Objective To investigate the drug regimens of children with Mycoplasma pneumoniae infection resistant to macrolide antibiotics. Methods From November 2010 to May 2012, Guangdong Provincial Maternal and Child Health Hospital admitted to the treatment of throat swab Mycoplasma pneumoniae positive children medication program, and re-visit medication. Results All of the 116 children with positive MP culture were treated with macrolide antimicrobial therapy, of which 52 were resistant, 3 were combined with β-lactam antibiotics, and 49 were resistant. The sensitive group was 64 cases, there is no combination of β-lactam antibiotics cases. The two groups of age, sex, macrolide antibacterial drugs, antipyretic drugs, antihistamines, the use of phlegm drugs was no significant difference, P> 0.05. The treatment course of macrolide antibacterials in resistant group was shorter than that in sensitive group, while the courses of antipyretic, antihistamine and phlegm were longer than those in sensitive group (P <0.05). Conclusion The macrolide antibiotic-resistant children with Mycoplasma pneumoniae infection were treated with macrolide antibiotics, antipyretic drugs, antihistamines and phlegm drugs, and macrolide antibiotics-susceptible Mycoplasma pneumoniae Infected children compared with drug-resistant macrolide antibacterials in patients with short course of treatment, the use of antipyretics, antihistamines and phlegm medicine treatment long.