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为探讨吸烟与温石棉在致癌过程中的联合作用，用已建株的人胚肺（ＨＥＬ）细胞在体外测定了烟溶液与温石棉单独及联合作用对细胞内芳香烃羟化酶（（ＡＨＨ）活性的影响。结果表明：烟溶液在剂量间虽也有一定的梯度变化，但在统计学上无显著性意义，而温石棉则可明显地诱导ＨＥＬ细胞内ＡＨＨ的活性升高，且有剂量－反应关系；当烟溶液与温石棉联合作用时对细胞ＡＨＨ活性的升高呈明显的相加作用，提示在吸烟与温石棉的联合作用过程中，温石棉可通过诱导ＡＨＨ活性升高，促使烟中的多环芳烃更易代谢为终致癌物，从而导致肺癌的发生
In order to investigate the combined effect of smoking and chrysotile asbestos in carcinogenesis, the effect of smoking solution and chrysotile both alone and in combination on the intracellular aromatase hydroxylase (AHH ) Activity.The results showed that there was a certain gradient between the doses of smoke solution, but there was no statistical significance, while chrysotile could obviously induce the increase of AHH activity in HEL cells, - reaction relationship; when the combination of smoking solution and chrysotile asbestos had an obvious additive effect on the AHH activity of cells, suggesting that during the combined action of smoking and chrysotile, chrysotile could induce AHH activity to promote PAHs in cigarettes are more easily metabolized to end-to-end carcinogens, leading to the development of lung cancer