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目的探究凯妮汀和制霉菌素栓剂通过阴道方式给药对外阴阴道念珠菌疾病反复发作实施治疗的安全性与临床效果。方法选取在陈星海医院接受治疗的88例外阴阴道念珠菌感染反复发作的患者作为研究对象,将其平均分为两组,凯妮汀组与制霉菌素栓剂组,分别通过阴道给药的方式给予凯妮汀以及制霉菌素栓剂治疗,对比分析两组研究对象出现不良反应的情况以及治疗的效果和复发情况。结果凯妮汀组研究对象不良反应发生率(4.54%)低于制霉菌素栓剂组(36.37%),两组比较,差异有统计学意义(P<0.05)。凯妮汀组研究对象总有效率(88.63%)高于制霉菌素栓剂组(63.63%),两组比较,差异有统计学意义(P<0.05)。凯妮汀组研究对象的复发率(6.82%)低于制霉菌素栓剂组(38.64%),两组比较,差异有统计学意义(P<0.05)。结论凯妮汀治疗外阴阴道念珠菌感染疾病反复发作的临床效果显著,安全性较高,较少复发,值得临床推广应用。
Objective To investigate the safety and clinical efficacy of civetine and nystatin suppositories for vaginal vaginal candidiasis by recurrent vaginal administration. Methods Eighty-eight patients with recurrent vulvovaginal candidiasis who were treated in Chen Xinghai Hospital were selected as study subjects and divided into two groups equally. Cortin and nystatin suppository groups were administered vaginally Given cinnidin and nystatin suppository treatment, comparative analysis of two groups of subjects adverse reactions as well as the treatment effect and recurrence. Results The incidence of adverse reactions in the cotinine group (4.54%) was lower than that in the nystatin suppository group (36.37%). There was significant difference between the two groups (P <0.05). The total effective rate (88.63%) in the cortisol group was higher than that in the nystatin suppository group (63.63%). There was significant difference between the two groups (P <0.05). The relapse rate (6.82%) in the cortinone group was lower than that in the nystatin suppository group (38.64%). There was significant difference between the two groups (P <0.05). Conclusion The clinical effect of cinnidin in recurrent vulvovaginal candidiasis is significant, safe and less recurrence, worthy of clinical application.