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用细胞胞浆分裂阻滞微核法（ＣＢＭＮ）研究了５名健康成人离体血（６０）￣Ｃｏ＿γ线低剂量（０．０３～１．０ Ｇｙ）照射后的淋巴细胞中含微核细胞（ＭＮＣ）及微核（ＭＮ）的剂量效应关系。结果表明，在低剂量范围内，ＭＮＣ率及ＭＮ率均随照射剂量的增加而增加，并可配合出拟合度良好的二次多项式模型。该模型适合于单次或短期内多次外照射的剂量估算，可望成为检测低剂量电离辐射的生物剂量计。结果还表明，应用ＭＮＣ率或ＭＮ率所能测得的最低剂量为０．０５Ｇｙ。当应用ＭＮ法估算低剂量的受照时，需注意年龄及既往射线、化学物质和药物的接触史，乃至吸烟等因素的影响。
Five healthy adult human lymphocytes that contained micronucleated cells (PBMCs) after irradiation with a low dose (0.03-1.0 Gy) of Co (60Co) (MNC) and micronuclei (MN) dose-response relationship. The results showed that in the low dose range, the MNC rate and MN rate increased with the increase of irradiation dose, and fitted with a good fitted quadratic polynomial model. The model is suitable for single or short-term dose estimation of multiple external exposure and is expected to become a biological dosimeter for detecting low dose ionizing radiation. The results also show that the lowest dose that can be measured using MNC or MN rates is 0.05 Gy. When using the MN method to estimate low-dose exposure, attention should be paid to the effects of age and exposure to previous radiation, chemicals and drugs, and even smoking.