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目的评价对晚期卵巢上皮性癌患者术后行紫杉醇静脉和顺铂腹腔灌注联合化疗的疗效及副反应。方法晚期卵巢上皮性癌26例行肿瘤细胞减灭术后,采用PT方案化疗,紫杉醇135mg/m2静脉滴注,顺铂60~80mg/m2腹腔灌注,4周为1疗程,平均6~8个疗程数。结果Ⅲ期总有效率为73.91%,Ⅳ期为33.33%。结论PT方案联合化疗效果好,毒副反应轻,有利于提高患者5年生存率和生存质量。
Objective To evaluate the efficacy and side effects of paclitaxel intravenous and cisplatin combined with intraperitoneal perfusion in patients with advanced epithelial ovarian cancer after operation. Methods Twenty-six patients with advanced epithelial ovarian cancer were treated with PT chemotherapy, intravenous infusion of paclitaxel (135mg / m2) and intraperitoneal injection of cisplatin (60-80mg / m2) for 4 weeks for 6 cycles Number of treatment. Results The total effective rate in stage Ⅲ was 73.91% and in stage Ⅳ was 33.33%. Conclusions The combination of PT and chemotherapy has good effect and mild side effects, which is beneficial to improve 5-year survival rate and quality of life of patients.