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目的:探讨p63,CK5/6,TTF1和napinsA在肺鳞癌和腺癌鉴别诊断中的价值。方法:应用免疫组织化学EnVision法分别检测42例肺鳞癌和42例肺腺癌中p63,细胞角蛋白5/6(cytokeratin 5/6,CK5/6),甲状腺转录因子1(thyroidtranscriptionfactor-1,TTF1)和napinsA的表达,同时分析它们对肺鳞癌和腺癌诊断的敏感性和特异性。结果:p63和CK5/6在肺鳞癌中的阳性表达率分别为100%和97.6%,明显高于TTF1和napsin A(P<0.01)。而TTF1和napsin A在肺腺癌中的阳性表达率分别为97.6%和100%,明显高于p63和CK5/6(P<0.01)。p63或CK5/6检测对肺鳞状细胞癌诊断的敏感性和特异性分别为100%和92.9%,TTF1和napsin A联合检测对肺腺癌诊断的敏感性和特异性分别为97.6%和100%。结论:p63,CK5/6,TTF1和napins A联合检测有助于肺鳞癌和腺癌的鉴别。
Objective: To investigate the value of p63, CK5 / 6, TTF1 and napinsA in the differential diagnosis of squamous cell carcinoma and adenocarcinoma. Methods: The expressions of p63, cytokeratin 5/6 (CK5 / 6) and thyroid transcription factor 1 (MMPs) in 42 squamous cell carcinomas and 42 adenocarcinomas of lung adenocarcinoma were detected by EnVision immunohistochemistry. TTF1) and napinsA expression, and analyze their sensitivity and specificity for the diagnosis of squamous cell carcinoma and adenocarcinoma. Results: The positive rates of p63 and CK5 / 6 in lung squamous cell carcinoma were 100% and 97.6%, respectively, which were significantly higher than those of TTF1 and napsin A (P <0.01). The positive rates of TTF1 and napsin A in lung adenocarcinoma were 97.6% and 100%, respectively, which were significantly higher than those of p63 and CK5 / 6 (P <0.01). The sensitivity and specificity of p63 or CK5 / 6 for the diagnosis of lung squamous cell carcinoma were 100% and 92.9%, respectively. The sensitivity and specificity of combined detection of TTF1 and napsin A for the diagnosis of lung adenocarcinoma were 97.6% and 100%, respectively %. Conclusion: The combination of p63, CK5 / 6, TTF1 and napins A can be helpful to distinguish squamous cell carcinoma from adenocarcinoma.