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本文以乙酰乙酸乙酯合成西咪替丁的中间体5-甲基-4-咪唑甲酸乙酯(1)。关于1的合成,已有报道,我们根据 Ertel 等的报道并参照欧洲专利加以改进。其合成路线如下:
In this paper, ethyl 5-methyl-4-imidazolecarboxylate (1) was synthesized using ethyl acetoacetate as cimetidine. As for the synthesis of 1, it has been reported that we have made improvements based on reports by Ertel et al. And with reference to European patents. The synthetic route is as follows: