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肛门浸润性鳞状细胞癌(SCC)是一种罕见的恶性病变,通常由肛门鳞状上皮内肿瘤(AIN)进展而来。美国的SCC和AIN发病率日益增高,部分因HPV的感染率升高而升高。肛门癌前鳞状上皮病变的组织学分级的高低,将直接影响到患者的治疗方案和预后。由于活检标本大多数较小、取材局限、组织学形态混杂等原因,目前仅通过活检标本来判断组织是否有浸润比较困难。CK17是由活化的角质形成细胞产生的一种基底细胞/肌上皮细胞角蛋白,多种研究显示CK17表达增强与子宫颈、食管和口腔鳞状细胞癌的进展相关。Nazarian等对
Anal infiltrating squamous cell carcinoma (SCC) is a rare malignant disease that usually progresses from an anorectal squamous intraepithelial neoplasia (AIN). The incidence of SCC and AIN in the United States is increasing, partly due to an increase in the prevalence of HPV infection. Anterior precancerous squamous cell lesions of the level of histological grade, will directly affect the patient’s treatment plan and prognosis. Due to the majority of biopsy specimens are small, limited access, histological morphology and other mixed reasons, the current biopsy specimens to determine whether the tissue infiltration is more difficult. CK17 is a basal / myoepithelial keratin that is produced by activated keratinocytes. Various studies have shown that increased expression of CK17 is associated with progression of cervical, esophageal and oral squamous cell carcinomas. Nazarian and so on