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目的：探讨中风患者血清ＮＯ含量的动态变化及其相应意义。方法：收集１９例脑梗塞１０例脑出血者以发病４ｈ、１２ｈ、２４ｈ、３ｄ、７ｄ五个时相用改良Ｇｒｉｅｓ法测血清ＮＯ代谢产物ＮＯ－ｘ（ＮＯ－２＋ＮＯ－３）的含量。结果：中风病人在发病４～７ｈ血清ＮＯ－ｘ值明显高于正常（Ｐ＜０．０１）。并且呈双峰趋势，梗塞及出血分别于３ｄ及２４ｈ时ＮＯ－ｘ值最高，梗塞与出血间以及大、小梗塞间无显著差异。结论：ＮＯ在超早期有脑保护作用，而在２４ｈ～３ｄ对脑组织损伤有重要的病理意义
Objective: To investigate the dynamic changes of serum NO level in patients with stroke and its corresponding significance. Methods: Nine patients with cerebral hemorrhage were collected from 19 patients with cerebral infarction. The levels of NO-x (NO-2 + NO-3) in the serum were detected by modified Gries method at 4h, 12h, 24h, 3d and 7d respectively. Results: Serum NO-x values of stroke patients were significantly higher than normal (P <0.01) 4 ~ 7h after onset. And showed a bimodal trend. The NO-x values were the highest at infarct and hemorrhage at 3d and 24h respectively. There was no significant difference between infarct and hemorrhage and between large and small infarcts. CONCLUSION: NO has a neuroprotective effect at an early stage and has important pathological significance in brain tissue injury at 24h ~ 3d