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目的：探讨水飞蓟宾对高脂饮食大鼠胰岛素敏感性的影响。方法：利用高脂饮食（ＨＦ）胰岛素耐受（ＩＲ）大鼠模型，观察水飞蓟宾对ＩＲ的治疗作用，与胰岛素增敏剂ＣＳ－０４５进行对照研究。用等热量ＨＦ饲养正常大鼠４周，分别以水飞蓟宾和ＣＳ－０４５灌胃治疗３周，测定动物体质量、血压、血糖、胰岛素、血脂、组织糖原、三酰甘油（ＴＧ）及胰岛素敏感性（Ｋ值）。结果：ＨＦ饲养４周时，大鼠胰岛素、血脂明显升高，肝脏和肌肉ＴＧ含量升高，糖原含量下降，胰岛素敏感性下降（Ｋ值为５．６３±０．７２），与正常对照组（７．７７±０．３５）比较，差异有显著性意义（Ｐ＜０．０１），７周时Ｋ值进一步下降。水飞蓟宾和ＣＳ－０４５治疗３周后，胰岛素敏感性改善，Ｋ值为５．０９±０．３９ｖｓ６．２２±０．５６（Ｐ＜０．０１），组织糖原含量明显增加（Ｐ＜０．０１）。结论：水飞蓟宾能改善ＨＦ大鼠的胰岛素敏感性，其机制可能与水飞蓟宾促进糖原合成有关。
Objective: To investigate the effects of silybin on insulin sensitivity of rats fed with high fat diet. METHODS: The high fat diet (HF) insulin resistance (IR) rat model was used to observe the therapeutic effect of silycin on IR, and a control study with insulin sensitizer CS-045. The normal rats were fed with isothermal HF for 4 weeks. The rats were treated with silybin and CS-045 for 3 weeks. The body weight, blood pressure, blood glucose, insulin, blood lipid, tissue glycogen, and triglyceride (TG) were determined. And insulin sensitivity (K value). RESULTS: At 4 weeks after HF feeding, insulin and blood lipids were significantly elevated in rats, TG content in liver and muscle increased, glycogen content decreased, and insulin sensitivity decreased (K value 5.63±0.72). There was a significant difference between the groups (7.77±0.35) (P<0.01), and K values decreased further at 7 weeks. After three weeks of treatment with silybin and CS-045, the insulin sensitivity was improved. The K value was 5.09±0.39 vs 6.22±0.56 (P<0.01), and the tissue glycogen content was significantly increased (P <0.01). CONCLUSION: Silybin can improve insulin sensitivity in HF rats, and its mechanism may be related to the promotion of glycogen synthesis by silybin.