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目的探讨角膜塑形镜联合体积分数0.01%阿托品控制青少年近视的临床效果。方法青少年近视患者94例(175眼),随机分为观察组47例(86眼)和对照组47例(89眼),2组均配戴角膜塑形镜,观察组同时给予体积分数0.01%阿托品滴眼,1滴/d。记录2组治疗前、治疗6个月后眼轴长度、瞳孔调节幅度、瞳孔直径、泪膜破裂时间,计算差值并进行比较。结果观察组治疗6个月后与治疗前眼轴长度差值[(0.11±0.09)mm]较对照组[(0.25±0.11)mm]小(P<0.05),瞳孔直径差值[(1.02±0.59)mm]较对照组[(0.05±0.85)mm]大(P<0.05);观察组、对照组治疗6个月后与治疗前瞳孔调节幅度差值[(-0.03±0.02)、(-0.05±0.04)D]、泪膜破裂时间差值[(-1.01±0.47)、(-1.04±0.59)s]比较差异均无统计学意义(P>0.05)。结论角膜塑形镜联合体积分数0.01%阿托品控制青少年近视效果优于单纯配戴角膜塑形镜,其机制可能与二者联合应用发挥协同作用,控制眼轴增长速度有关。
Objective To investigate the clinical effect of combined use of orthokeratology and 0.01% atropine in controlling juvenile myopia. Methods Ninety-four patients (175 eyes) with juvenile myopia were randomly divided into observation group of 47 cases (86 eyes) and control group of 47 cases (89 eyes) .One group was wearing orthokeratology lens. The observation group received 0.01% Atropine eye drops, 1 drop / d. The axial length, pupil adjustment amplitude, pupil diameter and tear film rupture time were recorded before treatment and 6 months after treatment. The differences were calculated and compared. Results The difference of axial length between the observation group and before treatment [(0.11 ± 0.09) mm] was smaller than that of the control group [(0.25 ± 0.11) mm] (P <0.05) 0.59) mm] was significantly higher than that of the control group [(0.05 ± 0.85) mm] (P <0.05); after 6 months of treatment, 0.05 ± 0.04) D], and the difference of tear film rupture time (-1.01 ± 0.47) and (-1.04 ± 0.59) s were not statistically significant (P> 0.05). Conclusion Ophthalmoscope combined with volume fraction of 0.01% atropine to control juvenile myopia is better than that of orthokeratology lens only. The mechanism may be related to their synergistic effect and the control of axial growth rate.