两例人淋巴细胞缺乏对低水平氚标记胸腺嘧啶和X射线照射后适应性反应的观察结果

• 作 者: 孙晓南
• 出 处: 国外医学(放射医学核医学分册)
• 发表日期: 1990年05期
• 关键词: 人淋巴细胞 适应性反应 X射线照射 氚标记 低剂量电离辐射 染色体畸变 供血者 亚硝基 硝基胍 胸腺嘧啶

Oliveri(1984年)首先报告了用~3H-TdR慢性预处理人淋巴细胞,可降低细胞对相继较大剂量X射线急性照射所诱导的染色体畸变的敏感性,并称之为适应性反应(AR).以后又被许多作者证实.然而,Morimoto用MNNG(1-甲基-1-亚硝基-3-硝基胍)诱导4例供血者淋巴细胞SCE时没有发现AR现象,认为AR存在着个体间的异质性.本文用已往曾经证明不能被低剂量电离辐射诱导AR的两个供血

Oliveri (1984) first reported that chronic pretreatment of human lymphocytes with ~3H-TdR can reduce the sensitivity of cells to chromosomal aberrations induced by successively large doses of X-ray radiation, and is called adaptive response (AR). Later, it was confirmed by many authors. However, Morimoto did not find an AR phenomenon in the lymphocyte SCE induced by MNNG (1-methyl-1-nitroso-3-nitroguanidine) in four donors. Heterogeneity between individuals. This article uses two blood supplies that have been shown to have been unable to induce AR by low dose ionizing radiation.