论文部分内容阅读
目的:探讨叶酸、维生素B_(12)对老年高血压伴高同型半胱氨酸(Hcy)血症患者的Hcy、一氧化氮(NO)、血压(BP)水平及脉搏波传导速度(PWV)的影响。方法:63例血清Hcy水平增高的高血压患者随机分为2组:(1)对照组(30例):仅服用降压、他汀类及阿司匹林等基础药物;(2)干预组(33例):除基础用药外加用叶酸(5mg/d)、维生素B_(12)(250μg/d)口服。治疗前(基线水平)及治疗后4周,测定患者空腹血清Bcy、NO水平,同时测量患者收缩压(SBP)、舒张压(DBP)及PWV。结果:干预组患者Hcy水平与服药前相比降低(P=0.0000);NO水平与服药前相比升高(P=0.0002);四周后对照组Hcy及NO水平亦有变化但无统计学差异(P>0.05)。两组患者SBP、DBP及PWV基线水平相比无统计学差异(P>0.05);干预组患者SBP、DBP及PWV值与治疗前相比降低均有统计学差异(P=0.0000)。结论:口服叶酸、维生素B_(12)可以显著改善老年高血压伴高Hcy血症患者的血管内皮功能及自主神经功能,有一定的降压及改善血管弹性的作用。
Objective: To investigate the effects of folic acid and vitamin B 12 on Hcy, nitric oxide (NO), blood pressure (BP) and pulse wave velocity (PWV) in elderly patients with hyperhomocysteinemia (Hcy) Impact. Methods: Sixty-three hypertensive patients with elevated serum Hcy levels were randomly divided into two groups: (1) control group (30 cases): taking only basic drugs such as hypotension, statins and aspirin; (2) intervention group (33 cases) : In addition to the basic medication plus folic acid (5mg / d), vitamin B 12 (250μg / d) orally. Before treatment (baseline) and 4 weeks after treatment, fasting serum Bcy and NO levels were measured and SBP, DBP and PWV were measured. Results: The Hcy level in the intervention group was significantly lower than that before treatment (P = 0.0000); the level of NO was increased as compared with that before treatment (P = 0.0002); the levels of Hcy and NO in the control group also changed after four weeks, but there was no significant difference (P> 0.05). There was no significant difference in SBP, DBP and PWV baseline between the two groups (P> 0.05). The SBP, DBP and PWV in the intervention group were significantly lower than those before treatment (P = 0.0000). Conclusion: Oral administration of folic acid and vitamin B 12 can significantly improve the vascular endothelial function and autonomic nervous function in elderly patients with hypertension and hyperhomocysteinemia, with certain antihypertensive effects and vascular elasticity improvement.