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目的 :在大鼠局灶栓塞性脑缺血模型上观察脑心通胶囊对神经肽的影响 ,探讨其治疗脑缺血的可能机制。方法 :采用FeCl3致大脑中动脉栓塞模型 ,应用放免法测定SD和自发性高血压大鼠 (HSR)血浆、下丘脑中ET和CGRP含量。结果 :脑心通可明显拮抗缺血 2 4h以内的血浆CGRP降低及ET的升高 ,提高SHR脑缺血时脑组织CGRP含量。结论 :脑心通主要对缺血早期ET及CGRP的异常变化有改善作用 ,而对缺血后期神经肽尚无明显影响 ,且以升高血浆及下丘脑中CGRP含量为主 ,对血浆ET的升高也有一定影响。
OBJECTIVE : To observe the effect of Naoxintong capsule on neuropeptides in a model of focal cerebral ischemia in rats and to explore its possible mechanism of cerebral ischemia. Methods :The middle cerebral artery occlusion model induced by FeCl3 was used to determine the levels of ET and CGRP in plasma and hypothalamus of SD rats and spontaneously hypertensive rats (HSR) by radioimmunoassay. Results: Naoxintong can significantly antagonize the decrease of plasma CGRP and the increase of ET within 24 hours after ischemia, and increase the content of CGRP in brain tissue of SHR during cerebral ischemia. Conclusion: Naoxintong mainly improves the abnormal changes of ET and CGRP in the early stage of ischemia, while it has no significant effect on the neuropeptides in the late stage of ischemia. It mainly increases the content of CGRP in plasma and hypothalamus, and it mainly affects plasma ET. The increase also has some effect.