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肠道的主要功能之一是阻止肠腔内细菌和内毒素移位到其他组织。肠屏障功能下降,致肠腔内大量细菌或内毒素向肠外组织迁移的过程称为细菌或内毒素移位。由肠道入血的细菌、内毒素随门静脉到达肝脏,首先被肝脏内皮细胞和枯否细胞吞噬、清除,从而在门静脉和全身循环之间构成了阻止内毒素或细菌进入体循环的一道屏障。近年来的研究发现,肠屏障功能低下及肠源性细菌或内毒素移位与外科重症患者的败血症、败血症综合征、高代谢状态、继发性组织细胞损害、多器官功能紊乱和多器官功能衰竭等并发症密切相关。因此,探讨肠道细菌或内毒素移位的机制和肠-肝屏障在肠道细菌和内毒素移位中的作用具有重要的临床意义。
One of the main functions of the intestine is to prevent the intestinal lumen bacterial and endotoxin translocation to other tissues. Intestinal barrier function decline, causing a large number of intestinal bacteria or endotoxin migration to the parenchyma process called bacterial or endotoxin translocation. Bacteria, which enter the bloodstream through the intestine, reach the liver through the portal vein and are first swallowed and cleared by the liver endothelial cells and Kupffer cells, thus forming a barrier between the portal vein and systemic circulation that prevents endotoxin or bacteria from entering the systemic circulation. In recent years, studies have found that intestinal barrier dysfunction and intestinal bacterial or endotoxin transposition and surgical critically ill patients with sepsis, sepsis syndrome, high metabolic status, secondary tissue damage, multiple organ dysfunction and multiple organ function Failure and other complications are closely related. Therefore, exploring the mechanisms of intestinal bacterial or endotoxin translocation and the role of the gut-liver barrier in intestinal bacterial and endotoxin transposition have important clinical implications.