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采用随机分组、自身交叉对比的方法，观察了格拉诺赛特（Ｇｒａｎｏｃｙｔｅ，ｒｈＧ－ＣＳＦ）和生白能（Ｌｅｕｃｏ－ｍａｘ，ｒｈＧＭ－ＣＳＦ）对晚期鼻咽癌ＰＩ方案（紫杉醇＋异环磷酰胺）强烈化疗后白细胞和血小板减少症的防治作用及毒副反应。患者随机分成Ａ、Ｂ两组（各１０例）。Ａ组第一周期化疗后加用格拉诺赛特，第二周期加用生白能；Ｂ组第一周期加用生白能，每二周期加用格拉诺赛特。两药均在化疗药物末次给药后２４ｈ起，１００μｇ／次，每日１次皮下注射。结果表明，格拉诺赛特减轻化疗引起的白细胞和中性粒细胞下降的程度、持续时间均比生白能的作用强。生白能似乎在促进血小板下降的恢复方面有一定的优势。
Randomized grouping and cross-contrast method were used to observe the PI plan of advanced nasopharyngeal carcinoma (Granocyte, rhG-CSF and Leuco-max, rhGM-CSF) (paclitaxel and ifosfamide). ) The prevention and treatment of leukocytes and thrombocytopenia after intense chemotherapy and its toxic and side effects. Patients were randomly divided into A and B groups (10 cases each). The first cycle of group A was followed by addition of grananoside and the second cycle was supplemented with white energy; the first cycle of group B was supplemented with white energy, and granosacide was added every second cycle. Both drugs were started at 24 h after the last administration of chemotherapeutic drugs, 100 μg/time, subcutaneously once daily. The results showed that Granolette reduced the degree of chemotherapy-induced leukocyte and neutrophil depletion and duration was stronger than that of raw white energy. It seems that raw white energy has certain advantages in promoting the recovery of platelet decline.