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卡介苗(bacille calmette-guerin,BCG)自从1921年法国医学家卡美特(A.Calmette)和兽医学家介云(C.Guerin)研制成功以来,被全球各国广泛用于预防结核病,迄今已有40亿人接种过BCG[1],我国自1954年开始对人群实施BCG接种,使机体建立特异性免疫力,对于有效地预防或减少结核病的发生起到了至关重要的作用[2]。尤其对结核性脑膜炎、粟粒性结核严重类型结核病有较好的预防效果,然而,由于疫苗本身、接种质量、
Bacille calmette-guerin (BCG) has been widely used in the prevention of tuberculosis by the French physician A. Calmette and veterinary scientist C. Guerin in 1921. So far, 4 billion people have been vaccinated with BCG [1]. Since 1954 BCG vaccination has been carried out in our country so that the body can establish specific immunity and play an essential role in effectively preventing or reducing the incidence of tuberculosis [2]. Especially for tuberculous meningitis, miliary tuberculosis severe type tuberculosis have a better preventive effect, however, due to the vaccine itself, the quality of vaccination,