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近年来已证明1,25(OH)_2维生素 D_3能直接抑制甲状旁腺素(PTH)的合成和分泌。本文旨在研究静脉用1(?)(OH)D_3能否抑制血透的继发性甲状旁腺功能亢进(甲旁亢)患者循环中的 PTH,而不引起口服相同剂量所致的高钙血症。病人21例,男13,女8例,平均年龄51岁。病人肌酐清除率(Ccr)为1～3ml/min,血透时间1个月～10年,每周3次。透析液 Ca~(++)浓度为1.5mmol/L。所有病人治疗前均未补充过1,25(OH)_2D_3。开始剂量1μg,以后每周递增1μg 直
In recent years, 1,25 (OH) 2 vitamin D 3 has been shown to directly inhibit the synthesis and secretion of parathyroid hormone (PTH). This article aims to investigate whether intravenous administration of 1 (?) (OH) D? 3 can inhibit PTH in the circulation of patients with secondary hyperparathyroidism (hyperparathyroidism) of hemodialysis without inducing hypercalcemia due to oral administration of the same dose Blood disorders. 21 patients, 13 males and 8 females, mean age 51 years old. Patients with creatinine clearance (Ccr) of 1 ~ 3ml / min, hemodialysis time of 1 month to 10 years, 3 times a week. Dialysate Ca ~ (++) concentration of 1.5mmol / L. All patients were not treated before treatment 1,25 (OH) _2D_3. The initial dose of 1μg, followed by an increase of 1μg per week straight