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本文报告一例高血压并发心、脑、肾功能不全患者,应用巯甲丙脯氨酸治疗获效,但引起急性药物性血小板减少性紫癜死亡, 患者,女,58岁,因头痛、头晕、血压高,曾多次住院系统治疗,服过多种降压药物.近半年来血压波动在22.7～25.3/14.7～17.3kPa之间,持续头晕,伴有活动后心悸气短,心情烦躁,简事易忘,尿少,睑面微肿,于1985年5月19日自感左下肢麻木无力,站立不稳,走路困难来院治疗。体检:心界向左下扩大,心尖区闻及1级收缩期杂音,左侧肢体偏瘫,左侧Babinskii征(+).脑CT、CTC检查提示左尾状核头及左内囊脑梗塞,心电图示偶发室早及冠脉供血不足表现,眼底及脑血流图示动脉硬化,尿蛋白(十),RBC 0-15/HP,肌酐159μmol/L,尿素氮7.9mmol/L,肾图曲线双侧呈水平延长型,K~+3.75mmol/L,
This article reports a case of hypertensive patients with heart, brain, kidney dysfunction, the application of captopril treatment, but caused by acute drug-induced thrombocytopenic purpura death, patients, female, 58 years old, due to headache, dizziness, blood pressure High, had many hospital system treatment, served a variety of antihypertensive drugs .In the past six months, blood pressure fluctuations between 22.7 ~ 25.3 / 14.7 ~ 17.3kPa, continued dizziness, accompanied by activity, heart palpitations, shortness of breath, irritability, easy Forget, oliguria, eyelid swelling, May 19, 1985 self-induced left lower limb numbness, standing instability, walking difficulties to hospital treatment. Physical examination: heart bound to lower left, apical zone and systolic level 1, left limb hemiplegia, left Babinskii sign (+). CT, CTC examination showed left caudate nucleus and left internal capsule cerebral infarction, electrocardiogram Ocular and cerebral blood flow showed arteriosclerosis, urinary protein (10), RBC 0-15 / HP, creatinine 159μmol / L, urea nitrogen 7.9mmol / L, Side was horizontal extension type, K ~ + 3.75mmol / L,