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目的:通过对子宫内膜癌组织中雌激素受体(ER)、孕激素受体(PR)表达水平的检测分析,探讨其临床意义。方法:应用免疫组织化学技术对70例子宫内膜癌组织进行ER、PR检测,结合临床及病理指标进行分析。结果:ER、PR在70例子宫内膜癌的阳性表达率分别为57.1%和58.57%,ER及PR的双阳性为50%。ER、PR在子宫内膜癌的阳性表达率与组织学分级有关,随组织学分级的增高,其阳性表达率逐渐降低,差异有显著性(P<0.01)。ER、PR的表达与临床分期,肌层浸润有关,差异有显著性(P<0.05)。与淋巴结转移差异无显著性(P>0.05)。结论ER、PR均反映了子宫内膜癌的生物学行为,是一个可以综合反映病程、病情和病变性质的客观指标,其测定对分析子宫内膜癌的预后和指导内分泌治疗具有重要意义。
Objective: To investigate the clinical significance of estrogen receptor (ER) and progesterone receptor (PR) expression in endometrial carcinoma. Methods: The expression of ER and PR in 70 cases of endometrial carcinoma was detected by immunohistochemical technique, and the clinical and pathological parameters were analyzed. Results: The positive rates of ER and PR in 70 cases of endometrial carcinoma were 57.1% and 58.57%, respectively. The positive rates of ER and PR were 50%. The positive expression rates of ER and PR in endometrial carcinoma were related with histological grade. With the increase of histological grade, the positive expression rate of ER and PR gradually decreased (P <0.01). The expression of ER and PR were correlated with clinical stage and myometrial invasion (P <0.05). There was no significant difference between lymph node metastasis and lymph node metastasis (P> 0.05). Conclusions Both ER and PR reflect the biological behavior of endometrial carcinoma, which is an objective index that can comprehensively reflect the course of disease, disease and pathological changes. The determination of ER and PR is of great significance for the analysis of the prognosis of endometrial carcinoma and the guidance of endocrine therapy.