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目的:研究红景天苷对大鼠血液流变学及离体心脏缺血再灌注损伤的影响。方法:用高分子右旋糖酐制备大鼠急性血瘀模型,观察其对血液流变学指标的影响;通过大鼠离体心脏缺血再灌注实验,观察红景天苷对冠脉流量和心肌收缩力的影响。结果:红景天苷(6、12、24 mg.kg-1)能有效预防急性血瘀模型大鼠全血粘度(高、中、低切变率)、血浆粘度、红细胞压积以及纤维蛋白原含量的升高;红景天苷(1.6、2.0、2.5 mg.L-1)能明显增加缺血再灌注后大鼠离体心脏冠脉流量,增强心肌收缩力。结论:红景天苷能显著改善急性血瘀模型大鼠的血液流变学,对大鼠离体心脏缺血再灌注损伤有一定的保护作用。
Objective: To study the effects of salidroside on hemorheology and ischemic reperfusion injury in isolated hearts in rats. METHODS: Rat acute blood stasis model was prepared with polymer dextran, and its effect on hemorheology was observed. The effects of salidroside on coronary flow and myocardial contractility were observed by isolated rat heart ischemia-reperfusion experiment. Impact. Results: Salidroside (6, 12, 24 mg.kg-1) can effectively prevent whole blood viscosity (high, middle and low shear rate), plasma viscosity, hematocrit, and fibrin in rats with acute blood stasis. The increase of the original content; salidroside (1.6, 2.0, 2.5 mg.L-1) can significantly increase the coronary blood flow of isolated rat heart after ischemia and reperfusion, and increase the myocardial contractility. Conclusion: Salidroside can significantly improve the hemorheology in rats with acute blood stasis and has a protective effect on isolated rat heart ischemia-reperfusion injury.