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目的系统评价存活蛋白(survivin)表达水平在乳腺癌(breast cancer)中表达水平及与人表皮生长因子受体2(cerbB-2)关系。方法计算机检索Cochrane Libtary(2011年第1期),PubMed、CNKI等数据库,并辅以手工检索,按照纳入与排除标准选择病例对照试验,评价质量及提取资料后采用Stata 11.0软件对数据库进行系统评价。结果共纳入16项研究,其中1330例乳腺癌患者,325例正常对照。Meta分析结果显示:survivin在乳腺癌组及正常对照组[比值比(odds ratio,OR)=51.34,95%可信区间(confidence interval,CI)=29.85-88.30]的表达差异具有统计学意义(P<0.05)。进一步生存分析显示,survivin阳性表达的乳腺癌患者5年生存率明显低于阴性者(OR=8.25,95%CI=1.89-35.96,P<0.05)。Spearman等级相关分析显示,survivin与cerbB-2蛋白阳性率在乳腺癌中表达具有相关性(r=0.275,P<0.05)。结论 survivin在乳腺癌中高表达,降低了乳腺癌患者5年生存率,同时survivin与cerbB-2在乳腺癌表达也有一定的相关性。
Objective To evaluate the expression of survivin in breast cancer and its relationship with human epidermal growth factor receptor 2 (cerbB-2). Methods The databases of Cochrane Libtary (2011 issue 1), PubMed, CNKI and so on were searched by computer and hand searched. The case-control trials were selected according to inclusion and exclusion criteria. The quality of the data was evaluated and the data were extracted. The data were then systematically evaluated using Stata 11.0 software . Results A total of 16 studies were included, including 1330 breast cancer patients and 325 normal controls. The results of Meta analysis showed that the difference of survivin expression between breast cancer group and normal control group [odds ratio (OR) = 51.34, 95% confidence interval (CI) = 29.85-88.30] was statistically significant P <0.05). Further survival analysis showed that the 5-year survival rate of survivin-positive breast cancer patients was significantly lower than that of the negative ones (OR = 8.25, 95% CI = 1.89-35.96, P <0.05). Spearman rank correlation analysis showed that the positive rate of survivin and cerbB-2 protein in breast cancer was correlated (r = 0.275, P <0.05). Conclusions Survivin is highly expressed in breast cancer, which decreases the 5-year survival rate of breast cancer patients. Meanwhile, survivin also has some correlation with the expression of cerbB-2 in breast cancer.