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目的 探讨食管癌浸润转移的SCT征象与MMP 7表达间关系。方法 46例食管癌术前行SCT增强扫描,术后标本采用免疫组织化学法检测肿瘤组织中MMP 7表达。结果 SCT对食管癌邻近结构有无受侵和有无淋巴结转移判断准确率为89.13%(41/46)和86.96%(40/46), 与手术病理结果一致性好(P<0.001)。MMP 7 阳性表达率为60.87%;邻近结构有、无侵犯组及淋巴结有、无转移组MMP 7 的阳性表达率分别为91. 67%, 50. 00%和87. 50%, 46. 67% (P<0.05)。结论 SCT征象可以反映食管癌MMP 7的表达情况及其生物学特性。
Objective To investigate the relationship between SCT sign and MMP 7 expression in esophageal carcinoma infiltration and metastasis. Methods Forty-six patients with esophageal cancer underwent SCT scan before operation. The expression of MMP-7 in the tumor tissue was detected by immunohistochemistry. Results The diagnostic accuracy of SCT for the adjacent structures of esophageal cancer and lymph node metastasis was 89.13% (41/46) and 86.96% (40/46), respectively, which was consistent with the results of surgical pathology (P <0.001). The positive expression rates of MMP-7 and MMP-7 were 60.87% and 91. 67%, 50. 00% and 87. 50%, 46. 67% respectively in the adjacent structures with or without infiltration and without lymph node metastasis (P <0.05). Conclusion SCT signs can reflect the expression of esophageal cancer MMP 7 and its biological characteristics.