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目的描述原发性椎管内肿瘤的临床特点和术后放疗的疗效,探讨影响疗效的因素。方法回顾性分析的33例原发性椎管内肿瘤患者中男18例,女15例,中位年龄37岁(7~64岁)。所有患者都接受了术后放疗。计算治疗的有效率、生存率以及判断患者、肿瘤和治疗相关的指标对于预后的影响。结果有效率、5年生存率和无瘤生存率分别为81.3%、59.4%和56.3%。多因素分析中病理类型和性别对5年生存率有影响,室管膜瘤的预后明显好于其他肿瘤,女性的预后好于男性;而年龄、手术切除范围、照射部位、剂量、手术与放疗间隔时间等与预后均无明显关系。结论放疗对于未完全切除的原发性椎管内肿瘤是安全有效的方法;病理类型和性别是影响原发性椎管内肿瘤的主要预后因素;术后放疗局部复发仍是死亡的主要原因。
Objective To describe the clinical features of primary spinal canal tumor and the efficacy of postoperative radiotherapy and to explore the factors influencing the curative effect. Methods Retrospective analysis of 33 patients with primary spinal canal tumor in 18 males and 15 females, the median age of 37 years (7 to 64 years). All patients received postoperative radiotherapy. Calculate the effectiveness of treatment, survival and to determine the prognosis of patients, cancer and treatment-related indicators. The results were effective, 5-year survival and tumor-free survival rates were 81.3%, 59.4% and 56.3%. In multivariate analysis, the pathological type and gender had an impact on the 5-year survival rate. The prognosis of ependymoma was significantly better than that of other tumors. The prognosis of women was better than that of males. However, the age, surgical resection scope, irradiation site, dosage, surgery and radiotherapy No significant relationship between prognosis and interval time. Conclusion Radiotherapy is a safe and effective method for primary resection of primary spinal canal tumor. Pathological type and gender are the main prognostic factors of primary spinal canal tumor. Local recurrence after radiotherapy is still the main cause of death.