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目的:探讨2型糖尿病肾病与血清C-反应蛋白(CRP)及尿微量清蛋白(MA)、α1-微球蛋白(α1-MG)的关系。方法:选择2型糖尿病146例为观察组,血糖正常者80例为对照组,采用免疫散射比浊法,测定两组血清CRP及尿MA、α1-MG水平,对其结果进行比较。结果:观察组血清CRP及尿MA、α1-MG水平均非常显著高于对照组(P<0.01),且血清CRP水平随尿MA、α1-MG排出水平增加而增高。结论:2型糖尿病肾损伤与血清CRP及尿MA、α1-MG水平关系密切。
Objective: To investigate the relationship between type 2 diabetic nephropathy and serum C-reactive protein (CRP), urinary microalbumin (MA) and α1-microglobulin (α1-MG). Methods: 146 patients with type 2 diabetes mellitus were selected as the observation group and 80 patients with normal blood glucose as the control group. The levels of serum CRP, urinary MA and α1-MG were measured by immune nephelometry. The results were compared. Results: Serum levels of CRP and urine MA and α1-MG in the observation group were significantly higher than those in the control group (P <0.01). Serum CRP level increased with the increase of urinary MA and α1-MG excretion. Conclusion: Type 2 diabetic renal injury is closely related to serum CRP, urinary MA and α1-MG levels.