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目的探讨脊髓亚急性联合变性(SCD)的临床与神经电生理特点。方法回顾性分析15例经临床和神经电生理确诊的脊髓亚急性联合变性的临床资料和神经电生理改变。结果感觉神经异常率100%,共查60条,感觉神经波幅(SANP)未引出28条,下肢20条,上肢8条,SNAP波幅降低24条,下肢8条,上肢16条,正常8条,其中上肢7条,下肢1条,传导速度减慢4条。SEP异常率87%,15例N9波幅降低13例,P40未引出8例,波幅降低或潜伏期延长5例,正常2例。结论 SCD有其特征性的电生理改变,神经电生理检查对早期诊断及预后起决定性作用。
Objective To investigate the clinical and neuroelectrophysiological characteristics of spinal subacute combined degeneration (SCD). Methods The clinical data and neuroelectrophysiological changes of 15 patients with subacute combined degeneration of spinal cord confirmed by clinical and electrophysiological methods were retrospectively analyzed. Results The sensory nerve abnormality rate was 100%. There were 60 cases in total. Sensory nerve amplitude (SANP) did not lead to 28, lower limbs, 8 upper limbs, 24 amplitude of SNAP, 8 lower limbs, 16 upper limbs, Of which 7 upper limbs, lower limbs 1, 4 slowdown of conduction velocity. SEP abnormality rate of 87%, 15 cases of N9 amplitude decreased in 13 cases, P40 did not lead to 8 cases, decreased amplitude or latency in 5 cases, normal in 2 cases. Conclusion SCD has its characteristic electrophysiological changes. Neurophysiological examination plays a decisive role in early diagnosis and prognosis.